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The CDC estimates depression causes 200 million lost workdays each year at a cost to employers of at least $17 billion.

What are the effects of depression on work life?

Researchers are looking at how precision motor control might be affected by major depression by looking at associated functional changes in the frontal brain regions

With an estimated 18.8 million American adults (or 9.5 percent of the working population) experiencing depression each year, most people know someone who is depressed—if they are not suffering themselves—and they understand how painful it can be. What is perhaps surprising is that about 80 percent of those with depression have some level of functional impairment as a result, according to the Centers for Disease Control and Prevention (CDC).

Depression is a major cause of disability, absenteeism and loss in productivity among working-age adults, with the CDC estimating 200 million lost workdays each year and a cost to employers of at least $17 billion. However, there is little laboratory-driven evidence of how or why depression impacts physical functioning.

As an assistant professor of Environmental and Occupational Health and director of the NeuroErgonomics Lab at the Texas A&M Health Science Center School of Public Health, Ranjana Mehta, Ph.D., studies the best ways to safeguard worker health and improve their performance. With a grant from the Hogg Foundation for Mental Health, Mehta plans to research how precision motor control might be affected by major depression by looking at associated functional changes in the frontal brain regions. “Knowing how depression impacts brain health,” Mehta said, “I wanted to see why and by how much depression impacts a worker’s physical ability to do his or her job safely.”

“Traditionally, human factors and ergonomics studies focus on operator performance and health in healthy young and older individuals,” Mehta said. Additionally, the research tends to be done in silos, with little connection between cognitive and physical branches of the field. “However, no task is done only using the brain or only using the body.” Mehta hopes this research will help connect the two by demonstrating that depression impacts physical functioning and that the mechanism is neurally-driven, probably in the frontal area of the brain, which controls higher reasoning and executive function. Some of Mehta’s previous research shows that after performing physical and mental tasks at the same time, the prefrontal cortex of the brain had lower oxygen levels, indicating accelerated fatigue development when performing tasks that require high physical and cognitive demands. Her current work will study this relationship in individuals with major depression.

Mehta and her team have experiments planned in which both depressed and non-depressed adult volunteers will perform precision motor tasks—such as grasping and knee extensions—while their brain and muscle activity and cardiovascular responses will be closely monitored. The data from the healthy controls will then be compared to that of the depressed individuals.

“We may be able to attribute changes in performance to specific brain function changes due to depression,” said Mehta, who is also the co-director of the Texas A&M Ergonomics Center, which studies worker performance, safety, and health.

The researchers hope that this work will generate preliminary findings that will help them design therapies to improve physical functioning in individuals suffering from work-related mental health issues. “Once we better understand these connections,” Mehta said, “interventions can be designed that can address the mechanism through both physical and mental training to improve not only depressive symptoms but also functional abilities.”

Mehta is one of only 10 tenure-track assistant professors throughout the state to receive the grant, which funds promising and innovative mental health research.

Media contact: Dee Dee Grays,, 979.436.0611

Christina Sumners

Communications Coordinator

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