Oral appliances can improve sleep apnea

The fallout from sleep apnea was severely affecting Jim Elliott’s life, but 10 years on a bulky CPAP breathing device wasn’t the answer. Instead, a simple plastic dental appliance has changed his life.

Elliott was one of 56 individuals diagnosed with moderate to severe sleep apnea who opted to participate in a Texas A&M University College of Dentistry Sleep Research Program study called “Randomized Trial of 2 Self-Titrated Oral Appliances for Airway Management.” The investigation compared two widely used oral appliance designs and concluded that their use dramatically improved patients’ breathing during sleep, as reflected in the respiratory event index. Results were published in the Journal of Dental Research in 2020.

Funded in part with $480,000 from the Baylor Oral Health Foundation and $75,000 of in-kind donations, the study compared midline traction versus bilateral thrust oral appliances. Such dental-inspired research to alleviate sleep apnea is among the latest in several ongoing clinical studies focused on using state-of-the-art oral appliances to manage the airway and, in turn, improve sleep and overall health.

“In that study we found they were both quite effective in treating their sleep apnea,” said Emet Schneiderman, PhD, director of the Sleep Research Program and professor in biomedical sciences at the College of Dentistry.

“The aspect of the study that was probably the most important was that we looked at people who had moderate and severe obstructive sleep apnea. The dogma forever has been that oral appliances are good for mild and moderate, but we found they are even more effective for people with severe sleep apnea,” Schneiderman said.

The CPAP, or Continuous Positive Airway Pressure machine, is considered successful if patients lower their score to below five on the apnea hypopnea index (AHI). AHI measures the number of apneas and hypopneas recorded per hour, which is when someone tries to breathe but their airway is fully or partially blocked. Thirty and above is considered severe, 29 to 15 is moderate and 14 to five per hour is mild.

The respiratory event index is an alternate measure that is readily acquired using a compact sleep-monitoring system in a person’s home—a feature of the Sleep Research Program’s clinical studies that makes it convenient for patients to participate. Prior to this type of system, sleep could only be studied in an overnight sleep laboratory, often a foreboding and expensive experience.

The ultimate goal is to reach fewer than five episodes each hour, which a CPAP is able to accomplish, Schneiderman says. Getting to that level using an oral appliance is a little harder. Yet current approaches are getting closer.

“A lot of us like to sleep on our backs. As we get older, the muscles of the throat become lax, and we also tend to put on weight. Those factors tend to conspire to close the airway at night,” Schneiderman said. “The tongue falls backward against the soft palate and back of the throat. If some air is allowed to pass through, it vibrates, and that’s snoring. If it’s completely closed, it’s apnea, where you quit breathing altogether.”

The oral apparatus that the Sleep Research Program is testing now—which resembles upper-and-lower night guards used for patients who grind their teeth—can be molded and fitted by qualified dentists chairside (next to the dental chair during treatment). The thermoplastic is heated until it’s almost a gel form, then placed in the patients’ mouths for a perfect fit.

“You fit it to the teeth, and it has an adjustment screw on it,” Schneiderman said. “By turning that, it brings the lower jaw forward. That has to be done very gradually and carefully and monitored so the jaw joint is not injured. We have to be very vigilant to preserve proper oral function and health. That’s a very good reason for a properly trained dentist to always be involved.”

The rise of a dental solution

Medicine has focused on CPAP, invasive surgeries and drugs for the treatment of obstructive sleep apnea. The emergence of oral appliance therapy as a viable solution for all severities has the potential to send many sleep apnea patients to their dentists instead of physicians as they search for solutions. The dental profession is gearing up to absorb that shift. Schneiderman estimates that more than a dozen dentists in the Dallas area—where the Texas A&M College of Dentistry is located—are properly trained in this therapy.

“When I first started treating sleep apnea, there were no continuing education courses available for dentists,” said Jason Hui, DDS ’11, an adjunct clinical faculty member and sleep dental medicine specialist who played a major role in conducting the study. “Nowadays, every continuing education conference has sleep apnea courses available for dentists to learn how to treat it. I believe the number of dentists able to treat sleep apnea will continue to rise.”

The cost for oral appliances for sleep apnea used to run in the thousands of dollars. But as they have become easier to make, the cost has come down considerably.

“The latest version that we’re working with is fit chairside, and the cost to the dentist is about $100,” Schneiderman said. “It’s very straightforward to fabricate by the dentist in about a half hour. That’s kind of revolutionary, too. It’s called myTAP.”

Rethinking CPAP 

In 2008, Elliott faced a health scare that resulted in wearing a Holter monitor to check his heart. With his heart stopping multiple times while he slept, he says his doctor planned to put in a pacemaker. During surgery, no electrical issues with his heart were found, so it was determined that sleep apnea was to blame.

At age 42, Elliott started using a CPAP. Like many other CPAP users, he found it uncomfortable and a hassle to take with him when he traveled.

CPAP works by using air to apply pressure on the throat. This prevents the airway from temporary collapse, and in so doing, prevents an interruption in breathing. Complaints of discomfort are so prevalent that even the Mayo Clinic offers a “top 10” list of how to avoid common problems. And that’s why alternatives to CPAP machines, such as dental appliances, are gaining positive traction.

“CPAP is not very natural. It tends to dry your nose and mouth. It does keep some people awake. That’s a drawback,” Schneiderman said. “For those who tolerate and wear it throughout the night, it’s great. But even among users, on average, they only wear it for about four hours a night.”

More men have obstructive sleep apnea than women, and it worsens with age and weight gain, according to a 2015 study published in The Journal of Thoracic Disease. Those under age 70 are at an increased risk of premature death, with strokes being a leading cause.

Oral appliance usage is becoming more widespread, Schneiderman said. The science supporting oral appliance therapy has come a long way since alumnus Keith Thornton, DDS ’69, invented his adjustable mandibular advancement appliance, the TAP, 27 years ago. With more than 72 patents, Thornton continues to be an outstanding innovator in the field of dental sleep medicine.

“There are now some key people in the sleep medicine field who understand that maybe starting someone on CPAP isn’t the only way to go. Maybe give them an option for one of these appliances,” Schneiderman said.

For Elliott and dozens of others like him in sleep studies, the results have been astounding.

Elliott’s life these days is a far cry from his previous experience of sleepless nights and difficult daytime meetings where he struggled to keep his eyes open.

“I was always tired but somehow rationalized it as normal,” Elliott said. “A long drive, a slow movie, every night after dinner I would find myself asleep. Boring meetings at work were torture. I never fell asleep, but it was often a battle. I even fell asleep at the wheel a few times but, thank god, no wrecks.”

Dental sleep medicine specialist Hui admits that he, too, struggles with sleep-disordered breathing, or pre-obstructive sleep apnea. Wearing an oral appliance every night has alleviated an issue he’s long struggled with, a condition he said many more people have than they realize.

Health issues considered

Sleep apnea has been linked to a variety of common diseases, including dementia, cardiovascular disease (high blood pressure, atrial fibrillation, congestive heart failure) and diabetes, among many others.

“If everyone completed a sleep study to rule out sleep apnea, and received proper treatment of sleep apnea, we would see a drastic drop in these ‘common’ diseases,” Hui said.

Schneiderman points out that in children who snore, one-third will eventually develop sleep apnea. In addition, 55 percent of children are mouth breathers according to a 2008 study, a red flag for what may await them in adulthood. Mouth breathing while sleeping reduces the benefits of saliva that protects teeth, and these patients are “more prone to developing caries, periodontal disease and discomfort,” the study states.

Humans are the only species that mouth breath. Our jaws are also becoming smaller, which may be caused by diet and air pollution, said Schneiderman, who is also a physical anthropologist. He notes that skeletons from before the industrial age display better developed jaws, more room for teeth, few orthodontic problems, and little caries (tooth decay).

The Sleep Research Program study’s preliminary findings are achieving the same low levels as a CPAP, which Schneiderman says they hope to demonstrate in the next few months. Reaching that goal would be a breakthrough.

“We hope to show that by eliminating mouth breathing, we will see improvements in the patients’ obstructive sleep apnea treatment (when compared to using an oral appliance alone, without the mouth shield), as well as improve the health of the gums and teeth,” Hui said.

Irwin Lightstone, who also participated in the earlier study, says mouth breathing has long been a problem for him. Since he started using an oral appliance (even without a shield), he has noticed marked improvement in long-standing periodontal issues. His latest dental checkup revealed less gum inflammation. A periodontal health score backs that up with hard numbers. Where he usually scored “fours” on his gum pockets, he’s now seeing “twos.” The higher the number, the higher the chances for bleeding and infection.

“My dentist was pleased,” Lightstone said. “I’m hoping this will slow the progress of my dental problems—including a history of cavities, crowns and root canals—which is very big.”

Far-reaching results

Trading in his CPAP for a palm-size and much more portable oral appliance has proven revolutionary for Elliott. Even though he says he felt better after he started using the CPAP, it kept him from a number of fun experiences, including camping.

“Now I can do anything anyone else can,” he said. “I am making the most of it.”

Elliott is still thanking his lucky stars that he happened to stumble across a call for sleep apnea participants for the College of Dentistry’s oral appliance study. He couldn’t have imagined how an easy sleep study, done from home with the school-supplied equipment, would be so metamorphic.

“The difference is hard to understand unless you have lived it,” he said.

Ongoing research initiatives 

A study investigating snoring and dementia, which appeared in Geriatrics in November 2021, sheds light on the impact of sleep quality in maintaining cognitive function in aging brains.

The team at Texas A&M College of Dentistry, in collaboration with the Center for BrainHealth at the University of Texas at Dallas, published this promising pilot study on treating snoring in people with mild cognitive impairment or early Alzheimer’s disease. This study on 18 older adults, also using the myTAP oral appliance, showed improvement in cognition in the majority of these patients.

To learn about enrolling in ongoing clinical trials and studies at the College of Dentistry, visit the college’s website.

This story by Kathleen Green Pothier originally appeared in Dentistry Insider